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Joseph Roney

DPhil Student

Axonal organelle transport in Niemann-Pick Type C

My work focuses on axonal organelle transport in healthy and diseased neurons. Our goal is to uncover mechanisms that contribute to altered axonal homeostasis in NPC using live-neuron imaging combined with genetic and pharmacologic approaches.

Key Points:

  • Proper transport is important in maintaining neuron growth, survival, and function but is particularly challenging with axons that can extend up to one meter in length
  • Lysosomes must navigate the cytoplasm appropriately to efficiently coordinate events throughout the cell
  • Axonal accumulation of organelles is common to both mouse and human NPC neuropathology, and precedes symptom-onset and neurodegeneration in NPC mice

Funding:

This work is supported by the Intramural Research Program of the National Institute of Neurological Disorders and Stroke, NIH

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