Skip to content

Axonal organelle transport in Niemann-Pick Type C

My work focuses on axonal organelle transport in healthy and diseased neurons. Our goal is to uncover mechanisms that contribute to altered axonal homeostasis in NPC using live-neuron imaging combined with genetic and pharmacologic approaches.

Key Points:

  • Proper transport is important in maintaining neuron growth, survival, and function but is particularly challenging with axons that can extend up to one meter in length
  • Lysosomes must navigate the cytoplasm appropriately to efficiently coordinate events throughout the cell
  • Axonal accumulation of organelles is common to both mouse and human NPC neuropathology, and precedes symptom-onset and neurodegeneration in NPC mice

This work was supported by the Intramural Research Program of the National Institute of Neurological Disorders and Stroke, NIH.

Back To Top The owner of this website has made a commitment to accessibility and inclusion, please report any problems that you encounter using the contact form on this website. This site uses the WP ADA Compliance Check plugin to enhance accessibility.