We are interested in lysosomal storage diseases; a family of over 50 individually rare metabolic disorders, that typically have a neurodegenerative clinical course. We are investigating underlying pathogenic processes in these disorders and using this information to develop new therapies to treat these diseases.
We are studying neuropathological and immunological deficits in these diseases, which is shedding light on lysosomal homeostasis and fundamental disease mechanisms.
We are also interested in determining the extent of lysosomal dysfunction in more common human diseases. Another area of interest is in biomarker development for clinical monitoring.
